"Epigenetics is the runtime configuration of life’s code, where the environment shapes the execution without altering the source."— Inspired by the dynamic interplay of biology and technology Introduction For software engineers skilled in managing c...
"The genome is the source code of life, and with the right tools, we can debug, optimize, and rewrite the future."— Inspired by the intersection of code and biology Introduction For software engineers, tackling complex systems—whether debugging micr...
If you’ve ever dabbled in high-throughput sequencing, genomics, or large-scale hypothesis testing, then chances are you’ve heard of False Discovery Rates (FDR). Maybe you’ve even used them. But have you ever paused to ask: Where do False Discovery R...
Introduction Imagine if we had a tool that could cut and edit DNA, the instruction manual of all living things, just like we edit text in a Word Document. That tool exists and it’s called CRISPR-Cas9. In this article, we will learn about: What is DN...
🎉 欢迎回来！ 🎉 准备好继续探索生物信息学的奇妙世界了吗？ 这次我们要攻克的是 BAM/SAM 文件！ 🚀 如果你已经掌握了VCF文件，那么BAM/SAM文件就像是它的“前传”或者“幕后花絮”。 理解 BAM/SAM 文件，你就能深入了解基因组数据的原始形态，以及变异是如何被检测出来的。 😎 教程大纲： BAM/SAM 文件是啥？为啥重要？ 🤔 （用大白话解释 BAM/SAM 的用途） SAM 文件格式解剖 🦴 （拆解 SAM 文件的结构，理解其组成部分） Header (头...
🎉 欢迎来到VCF文件101教程！ 🎉 想要像生物信息学忍者一样处理基因组数据吗？那么，理解VCF文件（Variant Call Format，变异位点格式）绝对是你的必修课！ 🚀 别担心，这篇教程就像是你的VCF速成班，目标是让你在看完后，能够自信地处理日常的VCF文件分析任务。 😎 教程大纲： VCF文件是啥？为啥重要？ 🤔 （用大白话解释VCF的用途） VCF文件格式解剖 🦴 （像拆骨头一样，把VCF文件结构拆开讲清楚） Header（头部）: 元数据信息，就像文件的“说...
In the spirit of “Learning in Public,” and “learning exhaust,” I’m adding “Lab Notes” blog posts that chronicle little discoveries or failures that I have along the way to a larger goal. This is a followup to my previous Lab Notes: Comparing GenePT a...
Hi there, and welcome to ocean code! Mangroves are quite slippery and marine ecosystems provide interesting healthcare services for local communities around the world. That's what I learned during a field trip to the Oprama creek at Buguma, Rivers St...
Introduction Childhood malnutrition remains a pressing global health issue, contributing to nearly half of all deaths among children under the age of five. Beyond immediate mortality, survivors often face long-term developmental impairments such as s...
The Dawn of a New Era in Biological Research Modern biology has undergone dramatic transformation through technological advancement. High-throughput sequencing technologies generate unprecedented volumes of data everyday. This scientific revolution d...
